Effects of intracerebral ventricular GLP-1(7-36) on blood glucose and its regulatory hormones in rats / 中国糖尿病杂志

After intracerebral ventricular administration of GLP-1 in NS or 30% glucose to rats,their effects on blood glucose and glucose regulatory hormones were observed. The results demonstrated:1. Intracerebral ventricular administration of GLP-1 in NS didn't influence plasma stucose, insulin and glucagon secretion.2. Intracerebral ventricular administration of GLP-1 in 30% glucose increased plasma glucose concentration significantly and decreased insulin concentration,but no change of glucagon concentration. This experiment showed that GLP-1 might participate in CNS regulation of pancreatic islet hormonesecretion.